Thank you. In a former life I spent a lot of time thinking about prevention at the end of the spectrum that you're referring to. I'm grateful for the question.
The classical remediable, preventable causes of chronic disease come to mind right away. We know them to be alcohol, tobacco, and obesity issues. Do those drive donation need? I don't have the epidemiology to back that up, but I would say instinctively that, just as you said diabetes, clearly I think another one to think about is misuse of prescription and non-prescription medication. Certainly I'd be questioning whether acetaminophen is a part of the underpinning of some of the organ failures where we see the need. I think it's a very good way to go to think about some of the interventions that can switch off some of the demand side.
We tend not to do the epidemiological analyses of the registries through that angle, through primary remediable cause. Certainly, we know what causes chronic illness.